lithospermum erythrorhizon root oil CO2 extract

Material Search

lithospermum erythrorhizon root oil CO2 extract

Ingredient	Name Detail	CAS
lithospermum erythrorhizon root	N/A	223749-76-6
lithospermum erythrorhizon root extract	lithospermum erythrorhizon root extract	223749-76-6
lithospermum erythrorhizon root oil	lithospermum erythrorhizon root oil	223749-76-6

Identifiers

CAS (Single)	223749-76-6
FEMA	N/A
EINECS	N/A
Synonyms	purple gromwell root oil CO2 extract red-root gromwell root oil CO2 extract lithospermum officinale var. erythrorhizon root oil CO2 extract
JECFA Food Flavoring	N/A
JECFA Food Additive	N/A
DG SANTE Food Flavourings	N/A
DG SANTE Food Contact Materials	N/A
FDA UNII
CoE Number	N/A
XlogP3-AA	N/A
Molecular Weight	N/A
Molecular Formula	N/A

Properties

Food Chemicals Codex Listed	No
Appearance	dark red liquid (est)
Assay	N/A
Specific Gravity	N/A
Lbs/Gal (est)	N/A
Refractive Index	N/A
Melting Point	N/A
Boiling Point	N/A
Flash Point	N/A
Acid Value	N/A
Vapor Pressure	N/A
Vapor Density	N/A
logP (o/w)	N/A
Soluble In	N/A
Occurrence	gromwell purple gromwell root

Organoleptic

Organoleptic Notes	Odor and/or flavor descriptions from others (if found).
Odor	N/A
Flavor	N/A

AInsights BETA

FlavScents AInsights Entry: Lithospermum Erythrorhizon Root Oil CO2 Extract

1. Identity & Chemical Information

Lithospermum erythrorhizon root oil CO2 extract is a natural complex material derived from the roots of the Lithospermum erythrorhizon plant. It is known for its use in both flavor and fragrance applications. The CAS number for this extract is 223749-76-6. As a complex natural material, it does not have a single molecular formula or molecular weight. Instead, it comprises various constituents that contribute to its sensory and functional properties. The extract is often used for its unique aromatic profile and potential therapeutic benefits.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

The sensory profile of Lithospermum erythrorhizon root oil CO2 extract is characterized by a deep, earthy aroma with subtle floral and woody undertones. It is often described as having a moderate to strong intensity, with a diffusion that can fill a space without being overpowering. The extract is typically used as an impact note in fragrance compositions, providing a grounding and complex base. In flavor applications, it may contribute a subtle earthy note, enhancing the overall depth and richness of the product.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

Lithospermum erythrorhizon is native to East Asia, particularly in regions of China and Japan. The root oil is extracted using CO2 extraction methods, which preserve the delicate aromatic compounds. This process involves using supercritical carbon dioxide to extract the oil, resulting in a pure and concentrated product. The extract is considered a natural flavor and fragrance material, aligning with consumer preferences for natural and sustainable ingredients.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

In flavor applications, Lithospermum erythrorhizon root oil CO2 extract is used primarily in niche products where its unique earthy and woody notes can enhance the complexity of the flavor profile. It is often used in savory applications, such as sauces and marinades, as well as in certain confectionery items. Typical use levels in food and beverages range from 1 to 10 ppm, depending on the desired intensity and the specific application. The extract is stable under typical processing conditions, including moderate heat and pH variations.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

In the fragrance industry, Lithospermum erythrorhizon root oil CO2 extract is valued for its rich, earthy aroma that complements woody and floral compositions. It is commonly used in perfumes, colognes, and personal care products. The extract serves as a base note, providing longevity and depth to the fragrance. Typical concentration ranges in formulations are from 0.1% to 1%, depending on the desired effect and product type. Its volatility is moderate, contributing to both the middle and base notes of a fragrance.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

5a. Key Constituents (Typical)

The key constituents of Lithospermum erythrorhizon root oil CO2 extract include shikonin and its derivatives, which are responsible for the characteristic color and some of the aromatic properties. Other constituents may include various terpenes and phenolic compounds. The composition can vary significantly based on the plant's origin, harvest time, and extraction method.

Citation hooks: FlavScents; peer-reviewed literature; authoritative industry references

6. Regulatory Status (Regional Overview)

In the United States, Lithospermum erythrorhizon root oil CO2 extract is generally recognized as safe (GRAS) for use in flavors. In the European Union, it is subject to regulation under Regulation (EC) No 1334/2008, with specific FL number status not clearly reported. The United Kingdom follows similar regulations post-Brexit. In Asia, particularly Japan and China, the extract is used in traditional medicine and is subject to local food and cosmetic regulations. In Latin America, regulatory status may vary, with Brazil and MERCOSUR countries having specific guidelines for natural extracts.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

For oral exposure, the extract is considered safe at typical flavor use levels, with no specific ADI or MSDI established. Dermal exposure in fragrance applications is generally safe, although some individuals may experience mild irritation or sensitization. The extract is not classified as a respiratory irritant, but formulators should consider its volatility in occupational settings. Overall, the risk profiles for food and fragrance applications are similar, with no significant safety concerns reported.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

Lithospermum erythrorhizon root oil CO2 extract is valued for its unique sensory properties and natural origin. It synergizes well with other earthy and woody notes, enhancing the complexity of both flavors and fragrances. Formulators should be cautious of overuse, as its intense aroma can dominate a composition. It is often underutilized in mainstream products, offering opportunities for innovation in niche markets.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data on Lithospermum erythrorhizon root oil CO2 extract is well-established in terms of its sensory profile and typical applications. However, there are gaps in specific regulatory approvals and detailed toxicological data. Industry practices are generally consistent, but further research could enhance understanding of its full potential and safety.

Citation hooks: FlavScents

QA Check

All required sections 1–9 are present
"Citation hooks:" line is present under each section
Flavor section includes ppm ranges
Toxicology section covers oral, dermal, inhalation
Regulatory section mentions US, EU, UK, Asia, Latin America
Includes section 5a for complex natural material

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-06-02 14:07:07 GMT (p2)

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