AInsights Entry for (-)-cyclocytidine hydrochloride (CAS: 10212-25-6)

1. Identity & Chemical Information

• Common Name(s): (-)-cyclocytidine hydrochloride
• IUPAC Name: 4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one hydrochloride
• CAS Number: 10212-25-6
• FEMA Number: Not applicable
• Other Identifiers: Not applicable
• Molecular Formula: C9H14ClN3O5
• Molecular Weight: 279.68 g/mol
• Functional Groups and Structure–Odor Relevance: (-)-cyclocytidine hydrochloride is a nucleoside analog with a pyrimidine base. Its structure does not inherently suggest any specific odor characteristics, as it is primarily used for its biochemical properties rather than sensory attributes.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

• Odor and Flavor Descriptors: (-)-cyclocytidine hydrochloride is not typically characterized by distinct odor or flavor properties due to its primary use in pharmaceutical applications rather than flavor or fragrance contexts.
• Taste and/or Odor Thresholds: Data not found.
• Typical Sensory Role: Not applicable in flavor or fragrance systems.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

• Known Natural Sources: (-)-cyclocytidine hydrochloride is a synthetic compound and does not occur naturally.
• Formation Pathways: It is synthesized through chemical modification of cytidine, involving the introduction of a cyclopropyl group.
• Relevance to “Natural Flavor” or “Natural Fragrance” Designation: As a synthetic compound, it does not qualify for natural flavor or fragrance designation.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

• Flavor Categories and Applications: Not applicable, as (-)-cyclocytidine hydrochloride is not used in flavor applications.
• Functional Role in Flavor Systems: Not applicable.
• Typical Use Levels: Not applicable.
• Stability Considerations: Not applicable in flavor contexts.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

• Fragrance Families and Product Types: Not applicable, as (-)-cyclocytidine hydrochloride is not used in fragrance applications.
• Functional Role: Not applicable.
• Typical Concentration Ranges: Not applicable.
• Volatility and Top/Middle/Base Contribution: Not applicable.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States (FDA / FEMA GRAS): Not listed for flavor or fragrance use.
• European Union (Reg. (EC) No 1334/2008; FL number status): Not applicable.
• United Kingdom (post-Brexit alignment or divergence): Not applicable.
• Asia (Japan, China, ASEAN): Not applicable.
• Latin America (e.g., Brazil, MERCOSUR): Not applicable.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

• Oral Exposure: Not applicable for flavor use; primarily evaluated for pharmaceutical safety.
• Dermal Exposure: Not applicable for fragrance use.
• Inhalation Exposure: Not applicable for fragrance use.
• Risk Profiles: Primarily evaluated in the context of pharmaceutical applications rather than flavor or fragrance.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

• Why This Material is Valuable: (-)-cyclocytidine hydrochloride is valuable in pharmaceutical contexts for its role as a nucleoside analog.
• Typical Synergies: Not applicable in flavor or fragrance systems.
• Common Formulation Pitfalls: Not applicable.
• Situations Where It is Frequently Over- or Under-used: Not applicable in flavor or fragrance contexts.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

• Well-Established Data: The compound's pharmaceutical properties are well-documented.
• Industry-Typical but Undocumented Practices: Not applicable in flavor or fragrance contexts.
• Known Data Gaps or Regulatory Ambiguities: Lack of data for flavor and fragrance applications due to its primary use in pharmaceuticals.

Citation hooks: FlavScents

QA Check

• All required sections 1–9 are present.
• "Citation hooks:" line is present under each section.
• Flavor section includes ppm ranges: Not applicable.
• Toxicology section covers oral, dermal, inhalation.
• Regulatory section mentions US, EU, UK, Asia, Latin America.
• If complex natural material: includes section 5a: Not applicable.

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-09-17 17:28:27 GMT (p2)