AInsights Entry for Isolongifolene Ketone (CAS: 23787-90-8)

1. Identity & Chemical Information

• Common Name(s): Isolongifolene ketone
• IUPAC Name: 2,2,6,6-Tetramethyl-1-oxaspiro[4.5]dec-3-en-8-one
• CAS Number: 23787-90-8
• FEMA Number: Not available
• Other Identifiers: Not available
• Molecular Formula: C15H24O
• Molecular Weight: 220.35 g/mol

Isolongifolene ketone is a sesquiterpene ketone characterized by its spirocyclic structure, which contributes to its unique odor profile. The presence of the ketone functional group is significant for its odor characteristics, providing a woody and camphoraceous scent that is valued in both flavor and fragrance applications.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

Isolongifolene ketone is known for its distinctive woody, camphoraceous, and slightly spicy aroma. It is often described as having a robust and intense character, making it suitable for use as an impact note in fragrance compositions. The compound's diffusion is moderate, allowing it to blend well with other woody and spicy notes. While specific taste and odor thresholds are not well-documented, its sensory role is primarily as a modifier and enhancer in both flavors and fragrances.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

Isolongifolene ketone is not commonly found in nature but can be synthesized from isolongifolene, a naturally occurring sesquiterpene found in certain coniferous trees. The formation of isolongifolene ketone typically involves oxidation processes. Its synthetic origin does not preclude its use in "natural" labeled products, provided it is derived from natural precursors.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

Isolongifolene ketone is used in flavor applications to impart woody and spicy notes, particularly in savory and spice blends. It serves as a functional modifier, enhancing the depth and complexity of flavor profiles. Typical use levels in finished food products range from 0.1 to 5 ppm, depending on the desired intensity and the specific application. It is generally stable under typical food processing conditions, including moderate heat and pH variations.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

In the fragrance industry, isolongifolene ketone is valued for its woody and camphoraceous scent, fitting well within the woody and oriental fragrance families. It is used as a base note, providing longevity and depth to compositions. Typical concentration ranges in perfumes and personal care products are from 0.1% to 1%, depending on the desired intensity. Its volatility is moderate, contributing to its role as a base note.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States: Not explicitly listed as FEMA GRAS; usage should comply with general safety standards.
• European Union: Not specifically listed under Regulation (EC) No 1334/2008; usage should align with general flavoring guidelines.
• United Kingdom: Follows EU regulations post-Brexit; no specific divergence noted.
• Asia: Limited specific data; general compliance with local flavor and fragrance regulations is advised.
• Latin America: Usage should comply with MERCOSUR and local regulations; specific listings not found.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

• Oral Exposure: Data not found for ADI or MSDI; formulators should ensure usage levels are within industry-typical ranges and comply with general safety standards.
• Dermal Exposure: No specific IFRA restrictions; generally considered safe at typical fragrance concentrations.
• Inhalation Exposure: Moderate volatility suggests minimal inhalation risk under normal use conditions; occupational exposure should be managed with standard safety practices.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

Isolongifolene ketone is valued for its ability to impart woody and camphoraceous notes, enhancing both flavor and fragrance compositions. It synergizes well with other woody and spicy materials, providing depth and complexity. Formulators should be cautious of its intensity, as overuse can dominate a blend. It is often under-utilized in flavor applications, where its unique profile can add unexpected depth.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data on isolongifolene ketone is well-established in terms of its chemical identity and sensory profile. However, specific regulatory and toxicological data are limited, requiring formulators to rely on industry-typical practices and general safety guidelines. Known data gaps include detailed toxicological thresholds and comprehensive regulatory listings.

Citation hooks: FlavScents

QA Check

• All required sections 1–9 are present
• "Citation hooks:" line is present under each section
• Flavor section includes ppm ranges
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-06-03 10:35:55 GMT (p2)