AInsights Entry for Indoxacarb (CAS: 173584-44-6)

1. Identity & Chemical Information

• Common Name(s): Indoxacarb
• IUPAC Name: Methyl (S)-7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]amino]carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate
• CAS Number: 173584-44-6
• FEMA Number: Not applicable
• Other Identifiers: Not applicable
• Molecular Formula: C22H17ClF3N3O7
• Molecular Weight: 527.84 g/mol
• Functional Groups and Structure–Odor Relevance: Indoxacarb is a synthetic oxadiazine pesticide. Its structure includes functional groups such as an oxadiazine ring, which is crucial for its insecticidal activity. However, it is not typically used for its odor properties in flavor or fragrance applications.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

Indoxacarb is primarily used as an insecticide and does not have a significant sensory profile relevant to flavors or fragrances. Its primary role is not related to odor or taste, and it is not typically evaluated for sensory characteristics in the context of flavor or fragrance formulation.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

Indoxacarb is a synthetic compound and does not occur naturally. It is manufactured through chemical synthesis processes designed to produce its specific insecticidal properties. As a synthetic pesticide, it does not qualify for "natural flavor" or "natural fragrance" designations.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

Indoxacarb is not used in flavor applications due to its primary function as an insecticide. It is not approved for use in food or beverages and does not have any documented flavor applications or typical use levels in ppm for such purposes.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

Indoxacarb is not used in fragrance applications. Its chemical properties and regulatory status as a pesticide preclude its use in perfumery or personal care products. It does not contribute to fragrance profiles or formulations.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States: Indoxacarb is registered as a pesticide with the Environmental Protection Agency (EPA) and is not approved for use in food flavors or fragrances.
• European Union: Regulated under pesticide regulations; not approved for flavor or fragrance use.
• United Kingdom: Follows EU regulations post-Brexit; not approved for flavor or fragrance use.
• Asia: Similar regulatory stance as in the US and EU; primarily registered as a pesticide.
• Latin America: Generally follows international pesticide regulations; not approved for flavor or fragrance use.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

• Oral Exposure: Indoxacarb is not intended for oral consumption and is not evaluated for ADI or MSDI in food applications.
• Dermal Exposure: As a pesticide, it may cause skin irritation; not relevant for fragrance use.
• Inhalation Exposure: Occupational exposure limits may apply; not relevant for fragrance use.

Indoxacarb's risk profile is primarily evaluated in the context of its use as a pesticide, not for flavor or fragrance applications.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

Indoxacarb is not relevant for flavor or fragrance formulators due to its classification and use as a pesticide. It does not provide any sensory benefits or functional roles in these industries.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data on indoxacarb is well-established in the context of its use as a pesticide. There is no industry-typical practice for its use in flavors or fragrances, and regulatory frameworks clearly delineate its approved uses.

Citation hooks: FlavScents

QA Check

• All required sections 1–9 are present
• "Citation hooks:" line is present under each section
• Flavor section includes ppm ranges (not applicable for indoxacarb)
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable for indoxacarb)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-05-25 06:49:51 GMT (p2)