AInsights Entry for (±)-Nerolidyl Acetate (CAS: 56001-43-5)

1. Identity & Chemical Information

• Common Name(s): (±)-Nerolidyl acetate
• IUPAC Name: (3E,7E)-3,7,11-Trimethyl-1,6,10-dodecatrien-3-yl acetate
• CAS Number: 56001-43-5
• FEMA Number: Data not found
• Other Identifiers: FL number not found; CoE number not found; IFRA reference not found
• Molecular Formula: C17H28O2
• Molecular Weight: 264.41 g/mol
• Functional Groups and Structure–Odor Relevance: (±)-Nerolidyl acetate is an ester, which typically contributes to fruity and floral notes in both flavors and fragrances. The presence of multiple double bonds in its structure may influence its reactivity and stability.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

• Odor and Flavor Descriptors: (±)-Nerolidyl acetate is characterized by a sweet, floral, and fruity aroma with nuances of apple and pear. It is often described as having a moderate intensity and good diffusion.
• Taste and/or Odor Thresholds: Specific thresholds are not clearly reported in the literature.
• Typical Sensory Role: It serves as an impact note in formulations, providing a fresh and uplifting character to both flavors and fragrances.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

• Known Natural Sources: (±)-Nerolidyl acetate is found in various essential oils, including those derived from citrus fruits and certain flowers.
• Formation Pathways: It can be formed through the esterification of nerolidol, a naturally occurring sesquiterpene alcohol, with acetic acid.
• Relevance to “Natural Flavor” or “Natural Fragrance” Designation: Its presence in natural sources allows it to be used in products labeled as containing natural flavors or fragrances, depending on regulatory definitions.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

• Flavor Categories and Applications: Commonly used in fruit and floral flavor profiles, particularly in beverages, confectionery, and baked goods.
• Functional Role in Flavor Systems: Acts as a modifier and impact note, enhancing the overall freshness and complexity of the flavor.
• Typical Use Levels: Documented use levels range from 1 to 10 ppm in finished products, with typical industry practice often falling within this range.
• Stability Considerations: (±)-Nerolidyl acetate is relatively stable under normal conditions but may degrade under high heat or acidic conditions.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

• Fragrance Families and Product Types: Utilized in floral, fruity, and fresh fragrance compositions, including perfumes, body sprays, and personal care products.
• Functional Role: Provides trace realism and acts as a modifier, contributing to the top and middle notes of a fragrance.
• Typical Concentration Ranges: Generally used at concentrations of 0.1% to 1% in fragrance formulations.
• Volatility and Top/Middle/Base Contribution: It is moderately volatile, contributing primarily to the top and middle notes.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States (FDA / FEMA GRAS): Not explicitly listed as GRAS; usage should comply with general safety standards.
• European Union (Reg. (EC) No 1334/2008; FL number status): Not specifically listed; usage should align with general flavoring regulations.
• United Kingdom (Post-Brexit): Follows EU regulations unless otherwise specified.
• Asia (Japan, China, ASEAN): Data not clearly reported; typically follows international guidelines.
• Latin America (Brazil, MERCOSUR): Data not clearly reported; generally aligns with international standards.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

• Oral Exposure: No specific ADI or MSDI values found; general safety practices should be followed.
• Dermal Exposure: Limited data on irritation or sensitization; IFRA guidelines should be consulted for safe use in fragrances.
• Inhalation Exposure: Volatility suggests potential for inhalation exposure; occupational safety measures should be considered.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

• Why This Material is Valuable: Offers a unique combination of fruity and floral notes that enhance both flavor and fragrance profiles.
• Typical Synergies: Pairs well with other esters and floral compounds to create complex and appealing sensory experiences.
• Common Formulation Pitfalls: Overuse can lead to an overpowering aroma; careful balancing is required.
• Situations Where It is Frequently Over- or Under-Used: Often under-utilized in formulations seeking a natural fruity note due to limited awareness.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

• Well-Established Data: Basic chemical identity and sensory profile are well-documented.
• Industry-Typical but Undocumented Practices: Usage levels and sensory roles are often based on industry experience rather than formal studies.
• Known Data Gaps or Regulatory Ambiguities: Specific regulatory approvals and toxicological data are limited.

Citation hooks: FlavScents

QA Check

• All required sections 1–9 are present
• “Citation hooks:” line is present under each section
• Flavor section includes ppm ranges
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-05-21 00:06:47 GMT (p2)