FlavScents AInsights Entry for Methyl Dihydroisojasmonate (CAS: 67845-52-7)

1. Identity & Chemical Information

• Common Name(s): Methyl dihydrojasmonate, Hedione
• IUPAC Name: Methyl 2-(3-oxo-2-pentylcyclopentyl)acetate
• CAS Number: 67845-52-7
• FEMA Number: 3497
• Other Identifiers: FL No. 09.821
• Molecular Formula: C13H22O3
• Molecular Weight: 226.31 g/mol

Methyl dihydroisojasmonate is a synthetic compound characterized by its ester functional group, which contributes to its floral and jasmine-like odor profile. The cyclopentanone ring structure is crucial for its olfactory properties, providing a balance of floral and fruity notes.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

Methyl dihydroisojasmonate is renowned for its delicate, floral aroma reminiscent of jasmine, with a subtle fruity undertone. It is often described as having a moderate intensity and excellent diffusion, making it a popular choice for both fine fragrances and functional products. The compound serves as an impact note in formulations, providing a naturalistic floral character. While specific odor thresholds are not widely reported, its effectiveness at low concentrations is well recognized in the industry.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

Methyl dihydroisojasmonate does not occur naturally but is synthesized for use in fragrances and flavors. Its structure is inspired by natural jasmonates, which are found in jasmine flowers and other plants. The synthetic pathway typically involves the esterification of cyclopentanone derivatives. Despite its synthetic origin, it is often used to impart a "natural" jasmine-like aroma in products.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

In flavor applications, methyl dihydroisojasmonate is used to impart floral and fruity notes, particularly in fruit and floral flavor categories. It acts as a modifier, enhancing the complexity and authenticity of flavor profiles. Typical use levels in finished food or beverage products range from 0.1 to 5 ppm, depending on the desired intensity and product type. It is stable under typical processing conditions, including moderate heat and pH variations, but may degrade under strong acidic or basic conditions.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

Methyl dihydroisojasmonate is a staple in the fragrance industry, used across various fragrance families, including floral, fruity, and chypre. It serves as a middle note, providing a long-lasting floral character that enhances the overall fragrance profile. Typical concentration ranges in perfumes are from 0.5% to 5%, depending on the desired intensity and product type. Its moderate volatility allows it to blend well with both top and base notes, contributing to the fragrance's overall harmony.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States: Recognized as GRAS by FEMA for flavor use.
• European Union: Approved under Regulation (EC) No 1334/2008 with FL No. 09.821.
• United Kingdom: Follows EU regulations post-Brexit with no significant divergence reported.
• Asia: Approved for use in Japan and China, with specific concentration limits varying by country.
• Latin America: Generally accepted in Brazil and MERCOSUR countries, with harmonized assumptions based on international standards.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

For oral exposure, methyl dihydroisojasmonate is considered safe at typical use levels, with no specific ADI established but generally recognized as safe under FEMA GRAS. Dermal exposure in fragrance applications shows low irritation and sensitization potential, aligning with IFRA guidelines. Inhalation exposure is considered safe under normal use conditions, with no significant occupational hazards reported. The risk profiles for food and fragrance applications are similar, with no major differences in safety considerations.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

Methyl dihydroisojasmonate is valued for its ability to impart a naturalistic jasmine aroma, enhancing both flavor and fragrance formulations. It synergizes well with other floral and fruity notes, providing depth and complexity. Common pitfalls include overuse, which can lead to an overpowering floral character, and underuse, which may result in a lack of impact. Formulators should balance its concentration carefully to achieve the desired sensory effect.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data on methyl dihydroisojasmonate is well-established, with comprehensive sensory and regulatory information available. Industry practices are well-documented, though some specific concentration thresholds in various applications may rely on industry-typical estimates. No significant data gaps or regulatory ambiguities are noted.

Citation hooks: FlavScents

QA Check

• All required sections 1–9 are present
• "Citation hooks:" line is present under each section
• Flavor section includes ppm ranges
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-06-04 11:30:14 GMT (p2)