2-isopropoxyethyl salicylate

Full Material List

N/A

Identifiers

CAS (Single)	79915-74-5
FEMA	N/A
EINECS	279-348-2
Synonyms	benzoic acid, 2-hydroxy-, 2-(1-methylethoxy)ethyl ester 2- hydroxybenzoic acid 2-(1-methyl ethoxy) ethyl ester 2- propan-2-yloxyethyl 2-hydroxybenzoate iso propoxyethyl salicylate sakura salicylate (Takasago)
JECFA Food Flavoring	N/A
JECFA Food Additive	N/A
DG SANTE Food Flavourings	N/A
DG SANTE Food Contact Materials	N/A
FDA UNII
CoE Number	N/A
XlogP3-AA	3.20 (est)
Molecular Weight	224.25632
Molecular Formula	C12 H16 O4

Properties

Food Chemicals Codex Listed	No
Appearance	colorless to pale yellow clear liquid (est)
Assay	98.00 to 100.00
Specific Gravity	1.08800 to 1.09400 @ 20.00 °C.
Lbs/Gal (est)	9.064 to 9.114
Refractive Index	1.50300 to 1.50600 @ 20.00 Â°C.
Melting Point	N/A
Boiling Point	281.00 to 282.00 Â°C. @ 760.00 mm Hg
Flash Point	309.00 Â°F. TCC ( 153.89 Â°C. )
Acid Value	N/A
Vapor Pressure	0.002000 mmHg @ 25.00 Â°C. (est)
Vapor Density	N/A
logP (o/w)	3.270 (est)
Soluble In	alcohol water, 213.3 mg/L @ 25 °C (est) water antiperspirant detergent fabric softeners soap
Occurrence	not found in nature

Organoleptic

Organoleptic Notes	1. Odor Type: floral Odor Strength:medium Substantivity: > 12 hour(s) at 100.00 % sweet floral balsamic herbal cherry Odor Description:at 100.00 %. sweet floral balsamic herbal cherry Odor and/or flavor descriptions from others (if found).
Odor	floral sweet, floral, balsamic, herbal, cherry,
Flavor	N/A

AInsights BETA

FlavScents AInsights Entry for 2-Isopropoxyethyl Salicylate (CAS: 79915-74-5)

1. Identity & Chemical Information

Common Name(s): 2-Isopropoxyethyl salicylate
IUPAC Name: 2-(Propan-2-yloxy)ethyl 2-hydroxybenzoate
CAS Number: 79915-74-5
FEMA Number: Not available
Other Identifiers: Not available
Molecular Formula: C12H16O4
Molecular Weight: 224.25 g/mol

2-Isopropoxyethyl salicylate is characterized by its ester functional group, which is crucial for its odor profile. The presence of the salicylate moiety contributes to its aromatic properties, often associated with sweet, floral, and balsamic notes.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

2-Isopropoxyethyl salicylate is known for its sweet, floral, and slightly balsamic odor. It is often described as having a moderate intensity with a smooth diffusion. The compound is typically used as a background note to enhance the overall realism of floral compositions in both flavors and fragrances. Specific odor thresholds are not well-documented, but it is generally used in low concentrations to avoid overpowering other components.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

This compound is not known to occur naturally and is typically synthesized for use in flavor and fragrance applications. Its formation involves the esterification of salicylic acid with 2-isopropoxyethanol. Due to its synthetic origin, it does not qualify for "natural flavor" or "natural fragrance" designations under most regulatory frameworks.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

2-Isopropoxyethyl salicylate is used in various flavor categories, including floral and sweet profiles. It acts as a modifier to enhance the complexity and depth of flavor systems. Typical use levels in finished food or beverage products range from 0.1 to 5 ppm, depending on the desired intensity and application. It is relatively stable under normal processing conditions but may degrade under extreme heat or acidic conditions.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

In fragrance formulations, 2-isopropoxyethyl salicylate is utilized in floral and oriental fragrance families. It serves as a middle note, providing a sweet and balsamic character that enhances the overall bouquet. Typical concentration ranges from 0.1% to 1% in the final product, depending on the desired effect. Its volatility is moderate, contributing to the fragrance's longevity.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

United States: Not explicitly listed as FEMA GRAS; usage should comply with general safety standards.
European Union: Not specifically listed under Regulation (EC) No 1334/2008; usage should align with general safety and labeling requirements.
United Kingdom: Follows EU regulations post-Brexit with no significant divergence reported.
Asia: Limited specific data; general safety and labeling standards apply.
Latin America: Usage should comply with regional safety standards; specific data not found.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

Oral Exposure: Data not found for specific ADI or MSDI values; usage should be guided by general safety assessments and industry practices.
Dermal Exposure: Generally considered safe for use in fragrances; no specific IFRA restrictions noted.
Inhalation Exposure: Moderate volatility suggests low risk under normal use conditions; occupational exposure should be minimized through standard safety practices.

Risk profiles do not significantly differ between food and fragrance applications, but formulators should ensure compliance with relevant safety standards.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

2-Isopropoxyethyl salicylate is valued for its ability to impart a sweet, floral character to formulations. It synergizes well with other floral and balsamic notes, enhancing the overall complexity. Common pitfalls include overuse, which can lead to an overpowering sweetness. It is often under-utilized in formulations seeking a subtle, naturalistic floral background.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data on 2-isopropoxyethyl salicylate is well-established in terms of its chemical identity and sensory profile. However, specific regulatory and toxicological data are less documented, requiring formulators to rely on industry-typical practices and general safety assessments.

Citation hooks: FlavScents

QA Check

All required sections 1-9 are present
"Citation hooks:" line is present under each section
Flavor section includes ppm ranges
Toxicology section covers oral, dermal, inhalation
Regulatory section mentions US, EU, UK, Asia, Latin America
If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-05-21 11:46:19 GMT (p2)

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