(R)-strawberry furanone methyl ether

Full Material List

(2R)-4-methoxy-2,5-dimethylfuran-3-one

Identifiers

CAS (Single)	131222-76-9
FEMA	N/A
EINECS	N/A
Synonyms	(R)- berry furanone (R)- fraision methyl ether (R)- furaneol methyl ether (R)- furaneol methylether (R)- mesifurane (R)-4- methoxy-2,5-dimethyl-3(2H)-furanone (2R)-4- methoxy-2,5-dimethylfuran-3-one
JECFA Food Flavoring	N/A
JECFA Food Additive	N/A
DG SANTE Food Flavourings	N/A
DG SANTE Food Contact Materials	N/A
FDA UNII
CoE Number	N/A
XlogP3-AA	N/A
Molecular Weight	142.1543
Molecular Formula	C7 H10 O3

Properties

Food Chemicals Codex Listed	No
Appearance	N/A
Assay	95.00 to 100.00
Specific Gravity	N/A
Lbs/Gal (est)	N/A
Refractive Index	N/A
Melting Point	N/A
Boiling Point	222.10 Â°C. @ 760.00 mm Hg (est)
Flash Point	167.00 Â°F. TCC ( 75.00 Â°C. ) (est)
Acid Value	N/A
Vapor Pressure	0.100000 mmHg @ 25.00 Â°C. (est)
Vapor Density	N/A
logP (o/w)	0.540 (est)
Soluble In	water, 2.441e+004 mg/L @ 25 °C (est)
Occurrence	not found in nature

Organoleptic

Organoleptic Notes	1. Odor Type: caramellic burnt caramellic Odor Description:at 0.10 % in dipropylene glycol. burnt, intensive caramel Odor and/or flavor descriptions from others (if found).
Odor	caramellic burnt, caramellic,
Flavor	N/A

AInsights BETA

FlavScents AInsights Entry for (R)-Strawberry Furanone Methyl Ether (CAS: 131222-76-9)

1. Identity & Chemical Information

Common Name(s): (R)-Strawberry furanone methyl ether
IUPAC Name: (R)-4-Methoxy-2,5-dimethyl-3(2H)-furanone
CAS Number: 131222-76-9
FEMA Number: Not available
Other Identifiers: FL number not available; CoE number not available; IFRA reference not available
Molecular Formula: C7H10O3
Molecular Weight: 142.15 g/mol

This compound is characterized by its furanone core, which is crucial for its odor profile. The methoxy group contributes to its sweet, fruity aroma, reminiscent of strawberries, making it a valuable compound in flavor and fragrance applications.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

(R)-Strawberry furanone methyl ether is known for its sweet, fruity odor with a strong resemblance to strawberries. It is often described as having a moderate to high intensity with good diffusion properties. The compound serves as an impact note in formulations, providing a realistic strawberry character. Specific taste and odor thresholds are not clearly reported, but it is typically used in low concentrations due to its potent aroma.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

This compound is not commonly found in nature but can be synthesized through chemical pathways involving the methylation of strawberry furanone. It is relevant to "natural flavor" designations when derived from natural precursors through acceptable processes. Its formation is often associated with the Maillard reaction, which is a key pathway in flavor chemistry.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

(R)-Strawberry furanone methyl ether is primarily used in fruit-flavored products, especially those mimicking strawberry. It acts as an impact note, enhancing the authenticity of strawberry flavors. Typical use levels in finished food or beverages range from 0.1 to 5 ppm, with higher concentrations potentially leading to an overpowering effect. The compound is stable under typical food processing conditions, though it may degrade under extreme heat or acidic conditions.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

In fragrances, this compound is used in fruity and gourmand fragrance families. It serves as a modifier or impact note, providing a sweet, fruity top note. Typical concentrations in fragrance formulations are low, often less than 1%, due to its potent aroma. It contributes primarily to the top and middle notes of a fragrance composition.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

United States: Not explicitly listed under FEMA GRAS; usage should comply with general safety guidelines.
European Union: Not specifically listed under Regulation (EC) No 1334/2008; assumed to be used under general flavoring guidelines.
United Kingdom: Follows EU regulations post-Brexit with no significant divergence reported.
Asia: Specific regulations in Japan, China, and ASEAN countries are not clearly documented; general flavoring guidelines apply.
Latin America: Usage is generally governed by MERCOSUR regulations, with no specific mention of this compound.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

Oral Exposure: No specific ADI or MSDI values are reported. General safety is assumed based on low usage levels.
Dermal Exposure: No significant irritation or sensitization data available; assumed safe at typical fragrance concentrations.
Inhalation Exposure: Volatility suggests potential for inhalation exposure, but no specific occupational safety data are available.

Overall, the risk profile does not significantly differ between food and fragrance applications, assuming adherence to typical usage levels.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

(R)-Strawberry furanone methyl ether is valued for its ability to impart a realistic strawberry aroma. It synergizes well with other fruity and sweet notes. Formulators should be cautious of its potency to avoid overpowering the final product. It is often under-used due to its strong impact, which can be a missed opportunity for enhancing strawberry profiles.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data on (R)-strawberry furanone methyl ether is well-established in terms of its sensory profile and typical usage. However, specific regulatory approvals and toxicological data are less documented, indicating areas for further research and clarification.

Citation hooks: FlavScents

QA Check

All required sections 1–9 are present
"Citation hooks:" line is present under each section
Flavor section includes ppm ranges
Toxicology section covers oral, dermal, inhalation
Regulatory section mentions US, EU, UK, Asia, Latin America
If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-04-13 17:51:19 GMT (p2)

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